I think “handsome” is a very subjective characteristic to begin with so some anime guys can be attractive to one category of people but not the other. But here are a few examples: Hisoka from Hunter x Hunter; Lancer from Fate Zero; Ban from 7 Deadly Sins; pretty much any guy from Free!; Natsu from Fairy Tail; Izaya from Durarara!; Sebastian from Black Butler; Gauche from Tegamibachi; and Gareki from Karneval. There are many more, however, anime is known for its hot guys and girls.